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Tech­ni­sche Uni­ver­si­tät Dres­den - Cen­ter for Mole­cu­lar and Cel­lu­lar Bio­en­gi­nee­ring (CMCB), B CUBE - Cen­ter for Mole­cu­lar Bio­en­gi­nee­ring, Chair of Mole­cu­lar Bio­phy­sics

The TU Dres­den is one of ele­ven Ger­man uni­ver­si­ties that were iden­ti­fied as an “excel­lence uni­ver­sity”. TUD has about 36.500 stu­dents and almost 5319 employees, 507 pro­fes­sors among them, and, thus, is the lar­gest uni­ver­sity in Sax­ony, today.

Having been com­mit­ted to sci­en­ces and the engi­nee­ring before the reuni­fi­ca­tion of Ger­many, TU Dres­den now is a multi-disci­pline uni­ver­sity, also offe­ring huma­nities and social sci­en­ces as well as medi­cine.

Research Asso­ci­ate / PhD Stu­dent / Postdoc

(Sub­ject to per­so­nal qua­li­fi­ca­tion employees are remu­ne­ra­ted accord­ing to salary group E 13 TV-L)
The posi­tion is avail­able star­ting at the next pos­si­ble date.
The posi­tion is limi­ted for one year with the pos­si­bi­lity of an exten­sion of two addi­tio­nal years. The period of employ­ment is gover­ned by the Fixed Term Rese­arch Con­tracts Act (Wis­sen­schafts­zeit­ver­trags­ge­setz-WissZeitVG).

Work­ing field:

lntra­cel­lu­lar mem­brane-bound organ­elles are spe­cial­ized to per­form spe­cific (bio)chem­ical reac­tions within the cell. However, organ­elles also com­mu­nic­ate and exchange their con­tent by fus­ing their mem­branes in a select­ive fash­ion. Such selectiv­ity is due to a set of spe­cific pro­teins that are devoted to tether organ­elle mem­branes and bring them closer for sub­sequent fusion. One teth­er­ing factor is the pro­tein EEA1, which gen­er­ates an act­ive pulling force by an entropic col­lapse (Mur­ray, Jahnel et al. Nature 2016). We hypo­thes­ize that this col­lapse is the res­ult of a long-range allos­teric com­mu­nic­a­tion along the coiled-coil struc­ture of EEA1.
We are look­ing for a PhD Stu­dent or a postdoc (bio­chem­ist or a bio­phys­i­cist) to reveal the mech­an­ism of the allos­teric coiled-coil col­lapse using state-of-the-art bio­chem­ical and single-molecule tech­niques, includ­ing single-molecule FRET.
For ques­tions please con­tact
Marino Zerial (zerial@mpi-cbg.de) or
Michael Schli­erf (michael.schlierf@tu-dresden.de).

Require­ments:

The pos­i­tion requires a uni­versity and - if applic­able - PhD degree in bio­chem­istry, bio­phys­ics or related fields. The applic­ant needs to have a pro­found back­ground in mem­brane asso­ci­ated pro­teins and their puri­fic­a­tion, and the use of state-of-the-art bio­chem­ical tech­niques. Exper­i­ence with single-molecule tech­niques is wel­come.
Excel­lent com­mu­nic­a­tion skills in Eng­lish are essen­tial as this is the lan­guage at the research centres.

What we of­fer:

The B CUBE (http://www.tu-dresden.de/bcube) and MPI CBG (http://www.mpi-cbg.de) as weil as their part­ner insti­tu­tions, the Bio­tech­no­logy Centre (BIO­TEC) and the Cen­ter for Regen­er­at­ive Ther­apies Dres­den (CRTD), are equip­ped with state-of-the-art facil­it­ies for Molecu­lar Bios­cience rese­arch.

How to ap­ply:

Applic­a­tions from women are par­tic­u­larly wel­come. The same applies to people with dis­ab­il­it­ies.
Com­plete applic­a­tions (let­ter of motiv­a­tion, CV, list of pub­lic­a­tions, and cer­ti­fic­ates of qual­i­fic­a­tions) should be sent via the

Secure­Mail Portal of the TU Dresden https://securemail.tu-dresden.de i
n a single pdf-file to antje.walter1@tu-dresden.de

or

via mail to
TU Dresden, B CUBE
Herrn Prof. Michael Schli­erf
Tatzberg 41
01307 Dresden

until 30.10.2019 (stamped arrival date applies).
Please sub­mit cop­ies only, as your applic­a­tion will not be returned to you. Expenses incurred in attend­ing inter­views can­not be reim­bursed.

Ref­er­ence to data pro­tec­tion: Your data pro­tec­tion rights, the pur­pose for which your data will be pro­cessed, as well as fur­ther inform­a­tion about data pro­tect ion is avail­able to you on the web­site: https://tu-dresden.de/karriere/datenschutzhinweis